Paediatric Pulmonology and Allergology

2004 October, Vol. VII, No. 2 (2534-2542)

Viral infection and wheezing child: new insights in treatment and prevention.

Laimute Vaideliene

Vi­rus in­fec­tion – most com­mon risk fac­tor for lo­wer res­pi­ra­to­ry tract obst­ruc­tion – whe­e­zing and ast­hma exa­cer­ba­tion in in­fants and tod­dlers. The im­mu­ne me­cha­nisms of vi­rus in­flam­ma­tion in he­alt­hy and ato­pic chil­dren still in­com­ple­te­ly un­ders­to­od. The ro­le of res­pi­ra­to­ry syn­cy­tial vi­rus (RSV) in­fec­tion in ato­pic sen­si­ti­za­tion is con­tro­ver­sial. The ef­fec­ti­ve tre­at­ment of whe­e­zing is im­pos­sib­le, not kno­wing the­se me­cha­nisms. The re­view be­low fo­cu­ses on pres­cho­ol chil­dren whe­e­zing phe­no­ty­pes, pos­sib­le me­cha­nisms of vi­rus in­flam­ma­tion in res­pi­ra­to­ry tract, long term and short term tre­at­ment op­tions. Re­sults of stu­dy PREVIA, dis­cus­sing new tre­at­ment op­tions of vi­rus in­du­ced whe­e­zing or ast­hma exa­cer­ba­tion are gi­ven be­low.

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